Unlike modern injections, the smallpox vaccine was delivered through multiple punctures of the skin, each introducing a small dose of the vaccine. This technique, while effective, inevitably led to localized inflammation and subsequent scarring. In the days following vaccination, the injection site would swell temporarily before returning to normal. However, a more pronounced reaction would occur approximately six to eight weeks later. A small lump, reminiscent of a mosquito bite, would develop and gradually transform into a raised lesion. This lesion would eventually ulcerate and ooze fluid before finally healing, leaving behind the indelible mark that serves as a silent sentinel of a vanquished foe.

Thanks to the tireless efforts of global health organizations and medical professionals, smallpox was officially eradicated in 1980. As a result, routine smallpox vaccinations ceased in the 1980s, rendering the distinctive scar a relic of a bygone age. Yet, this seemingly insignificant mark continues to hold historical significance, serving as a poignant reminder of a once-deadly disease and the triumph of human ingenuity over adversity.